Primary sclerosing cholangitis: A review and update
نویسندگان
چکیده
منابع مشابه
Update on primary sclerosing cholangitis.
Early studies in primary sclerosing cholangitis (PSC) were concerned with disease characterization, and were followed by epidemiological studies of PSC and clinical subsets of PSC as well as a large number of treatment trials. Recently, the molecular pathogenesis and the practical handling of the patients have received increasing attention. In the present review we aim to give an update on the ...
متن کاملPrimary sclerosing cholangitis - a comprehensive review.
Primary sclerosing cholangitis (PSC) is a rare disorder characterised by multi-focal bile duct strictures and progressive liver disease. Inflammatory bowel disease is usually present and there is a high risk of cholangiocarcinoma and colorectal cancer. Most patients ultimately require liver transplantation, after which disease recurrence may occur. With limited therapeutic options and a lack of...
متن کاملPrimary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disorder of the biliary system that results in progressive fibrosis and strictures of the intrahepatic and extrahepatic bile ducts. Typical radiological changes on retrograde cholangiography are shown in Figure 1. These strictures cause cholestatic liver disease that may progress to end-stage cirrhosis. The disorder has a strong ass...
متن کاملPrimary Sclerosing Cholangitis: Introduction
The prevalence of primary sclerosing cholangitis in the United States is approximately 1–6 cases per 100,000 population. Most patients with primary sclerosing cholangitis are men (75%) with an average age of approximately 40 years at diagnosis. The overwhelming majority of patients affected with primary sclerosing cholangitis are Caucasian. The etiology is unknown but current opinion favors an ...
متن کاملPrimary sclerosing cholangitis.
PRIMARY sclerosing cholangitis, stenosing cholangitis, fibrosing cholangitis, chronic obliterative cholangitis are all terms referring to a rare diffuse type ofchronic inflammation of the entire common bile duct and at times of the hepatic ducts and their radicles. In most instances, sclerosing cholangitis is idiopathic or primary. Bartholomew et al., in 1963 found only twenty unequivocal cases...
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ژورنال
عنوان ژورنال: Liver Research
سال: 2017
ISSN: 2542-5684
DOI: 10.1016/j.livres.2017.12.002